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Reconstitution diluent · benzyl-alcohol preserved
Also known as Bacteriostatic water · preserved diluent
Sterile water with a benzyl alcohol preservative, used to reconstitute lyophilized research compounds. For research use only.
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Tested lot by lot at ≥99% purity. The Janoshik certificate for your lot is emailed with the order.
Everything Valtrax Research ships is bench material for in-vitro work. None of it is a drug, a supplement, a cosmetic, or a medical device, and none of it is intended for human or animal use, ingestion, or administration. Placing an order is your confirmation that you are a qualified researcher buying for lawful research, under every Canadian law and regulation that applies to you.
Water with a benzyl alcohol preservative — the only item in this catalog that is not a research compound. Its purpose is dissolution: lyophilized material has to go into solution before anything can be measured, and the preservative is what allows a multi-draw vial to be entered more than once without the contents turning into a culture.
Benzyl alcohol is the reason the vial behaves the way it does, and it is also the reason compatibility matters. The preserved diluent literature is largely a record of which preparations tolerate it and which do not.
There is no pharmacology to summarize here — the literature treats bacteriostatic diluent as a variable rather than a subject. What gets studied is compatibility with the compound being dissolved, stability and preservative effectiveness over the life of an opened vial, and how preserved solutions compare with unpreserved ones in practice.
The working properties are the point. Benzyl alcohol suppresses bacterial growth in the vial, so the container tolerates repeated withdrawal in a way unpreserved water does not, and that is what makes it the default for reconstituting lyophilized stock.
The trade-off is chemical compatibility. Preserved diluents are not inert toward everything they touch, and the published record includes both documented incompatibilities and preparations whose stability and preservative effectiveness hold up after dilution. Which case applies is a property of the compound being dissolved, not of the water.
Benzyl-alcohol-preserved water and saline entered routine use as multi-dose diluents, and most of the literature that followed is practical rather than mechanistic: compatibility reports, stability and preservative-effectiveness work after dilution, and comparisons of preserved saline against other agents in clinical settings.
The useful lesson from that record is the negative one. An incompatibility documented in 1988 between an alkylating agent and benzyl-alcohol-preserved water remains the standard illustration that the diluent is a variable in the experiment, not a neutral background.
Behme, RJ. et al. (1988). Incompatibility of ifosfamide with benzyl-alcohol-preserved bacteriostatic water for injection.
PubMedCorbo, DC. et al. (1992). Stability, potency, and preservative effectiveness of epoetin alfa after addition of a bacteriostatic diluent.
PubMedMcNelis, KA. (1998). Intradermal bacteriostatic 0.9% sodium chloride containing the preservative benzyl alcohol compared with intradermal lidocaine hydrochloride 1% for attenuation of intravenous cannulation pain.
PubMedHunt, SV. et al. (2022). Bacteriostatic preserved saline for pain-free periocular injections: review.
PubMedThis is a diluent, not a research compound. The independent Janoshik certificates included with an order cover the compounds in it; they do not describe the water.
Janoshik Analytical, a laboratory Valtrax does not own, runs the testing — identity by mass spectrometry, purity by RP-HPLC at ≥99%. The certificate covering the lot you receive is also emailed with your order.
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