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Pentadecapeptide · gastric-derived
Body Protection Compound-157. A 15-amino-acid peptide studied in experimental models of structural repair and angiogenic pathway regulation.
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Assayed by Janoshik to ≥99% purity — the certificate is included with every order.
Valtrax Research supplies materials strictly for in-vitro laboratory research. They are not drugs, supplements, cosmetics, or medical devices, and are not intended for human or animal use, ingestion, or administration. By ordering, you confirm you are a qualified researcher purchasing for lawful research use, in accordance with all applicable Canadian laws and regulations.
Fifteen residues, sequenced from a stretch of human gastric juice protein. BPC-157 has no native parent molecule that circulates on its own — the fragment is the article of study, made stable enough to hold up in solution where most short peptides break down.
What keeps it on the bench is reach. The same sequence shows up across tendon, vascular, and gut models, which is why the literature returns again and again to angiogenesis and the nitric-oxide axis rather than to any one tissue.
Most of the published work sits in three buckets: tissue repair, vascular response, and gut/cytoprotection. Across them the data point back to angiogenesis, eNOS-linked vascular tone, and collagen remodeling — the mechanistic spine that ties the otherwise unrelated models together.
BPC-157 — Body Protection Compound 157 — is a 15-residue fragment first written up in the early 1990s, when groups screening gastric juice for organoprotective activity isolated the parent protein and narrowed it to this stretch. The fragment proved unusually robust in aqueous conditions, which is what made it tractable to study.
The recurring threads in the work are angiogenesis, endothelial nitric-oxide signaling via the Src–Caveolin-1–eNOS route, and collagen turnover. Read together, those threads explain why connective-tissue, vascular, and cytoprotection models all keep reaching for the same sequence.
The compound came out of gastric-peptide screening, where the first models were about mucosal integrity and ulcer response. From there the question widened: tendon, ligament, vascular, and dermal preparations followed, each testing whether the same fragment behaved consistently outside the gut.
The answer was reproducible enough across labs that BPC-157 settled in as a standing reference point in preclinical repair literature.
Sikirić, P. et al. (1993). A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. J Physiol Paris 87(5):313–327.
PubMedStaresinic, M. et al. (2003). Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res 21(6):976–983.
PubMedChang, C.H. et al. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985) 110(3):774–780.
PubMedHuang, T. et al. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther 9:2485–2499.
PubMedHsieh, M.J. et al. (2020). Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Sci Rep 10(1):17078.
PubMedDuzel, A. et al. (2017). Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights. World J Gastroenterol 23(48):8465–8488.
PubMedVukojević, J. et al. (2020). The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats. Brain Behav 10(8):e01726.
PubMedKolovrat, M. et al. (2020). Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion. World J Hepatol 12(5):184–206.
PubMedIndependently verified — identity, purity, and net peptide content.
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