What is PT-141 studied for?

PT-141 (Bremelanotide) is a melanocortin receptor agonist studied in the sexual-function literature. Unlike PDE5 inhibitors, which act on the vascular pathway, PT-141 acts centrally on melanocortin receptors in the nervous system. Valtrax supplies it as a laboratory research compound only.

What is the difference between PT-141 and Melanotan II?

PT-141 is a metabolite of Melanotan II and is considerably more selective. Melanotan II is a non-selective melanocortin agonist whose primary published action is at MC1R on melanogenesis, with secondary effects on appetite and sexual function through MC3R and MC4R.

What does Kisspeptin-10 do in research models?

Kisspeptin-10 acts on the GnRH neurons that gate the hypothalamic-pituitary-gonadal axis. Published research covers LH and FSH release, puberty onset, fertility and its use as a diagnostic probe of reproductive-axis function.

Are these compounds independently tested?

Yes. Janoshik Analytical confirms identity by mass spectrometry and purity by RP-HPLC at 99% or better for every lot.

04 / Shelf

Melanocortin & Reproductive Peptides

The melanocortin system sits at the intersection of pigmentation, appetite and sexual function, which is why this shelf covers ground that looks unrelated at first glance. PT-141 and Melanotan II are melanocortin receptor agonists, studied respectively in the sexual-function and melanogenesis literature. Kisspeptin-10 acts further upstream on the reproductive axis, at the GnRH neurons that govern LH and FSH release. These are among the most-searched research peptides in Canada and among the most frequently misrepresented, so every lot here is independently purity tested.

3 compounds on this shelf

Research Peptide

PT-141

$44.99

10mg

Bremelanotide. A synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone. Supplied as a lyophilized powder for research purposes only.

Research Peptide

Kisspeptin-10

$40.00

10mg

The C-terminal decapeptide of KISS1 and a full agonist at KISS1R (GPR54). Supplied as a lyophilized powder for research purposes only.

Research Peptide

Melanotan II

$40.00

10mg

A cyclic lactam heptapeptide analogue of alpha-MSH, engineered to resist the proteases that clear the linear hormone. Supplied as a lyophilized powder for research purposes only.

PT-141 and the sexual-function literature

PT-141, or Bremelanotide, is a cyclic heptapeptide and a metabolite of Melanotan II. Its research record is distinctive because it acts centrally, at melanocortin receptors in the nervous system, rather than on the vascular pathway that PDE5 inhibitors target. That mechanistic difference is the reason it developed a separate clinical literature covering desire rather than vascular response, and it is why the compound is studied in both male and female models. The published work also documents transient effects on blood pressure and nausea that are characteristic of melanocortin agonism generally.

Melanotan II and melanogenesis

Melanotan II is a non-selective melanocortin agonist and the more promiscuous compound of the pair. Its best-documented action is at MC1R, where the published research concerns melanogenesis — the stimulation of eumelanin synthesis, which is what generated the original interest in it as a photoprotection candidate. Because it engages MC3R and MC4R as well, the literature also records effects on appetite and sexual function, and it is the parent compound from which PT-141 was derived. Non-selectivity is the defining feature of its research profile and the source of most reported adverse findings.

Kisspeptin-10 and the reproductive axis

Kisspeptin-10 works at a different level entirely. It is the decapeptide fragment of kisspeptin, the neuropeptide that gates GnRH release and therefore sits upstream of the entire hypothalamic-pituitary-gonadal axis. The research covers puberty onset, LH pulsatility and fertility, and its role as a diagnostic probe of reproductive-axis function. Its half-life is short, which shapes the administration protocols reported in the literature. Grouping it with the melanocortins reflects a shared subject area rather than a shared mechanism.

Questions

Melanocortin & Reproductive peptides — common questions

What is PT-141 studied for?: PT-141 (Bremelanotide) is a melanocortin receptor agonist studied in the sexual-function literature. Unlike PDE5 inhibitors, which act on the vascular pathway, PT-141 acts centrally on melanocortin receptors in the nervous system. Valtrax supplies it as a laboratory research compound only.
What is the difference between PT-141 and Melanotan II?: PT-141 is a metabolite of Melanotan II and is considerably more selective. Melanotan II is a non-selective melanocortin agonist whose primary published action is at MC1R on melanogenesis, with secondary effects on appetite and sexual function through MC3R and MC4R.
What does Kisspeptin-10 do in research models?: Kisspeptin-10 acts on the GnRH neurons that gate the hypothalamic-pituitary-gonadal axis. Published research covers LH and FSH release, puberty onset, fertility and its use as a diagnostic probe of reproductive-axis function.
Are these compounds independently tested?: Yes. Janoshik Analytical confirms identity by mass spectrometry and purity by RP-HPLC at 99% or better for every lot.

Other research shelves

Skin & Cosmetic

GHK-Cu, Melanotan II and the GLOW and KLOW blends — copper peptides and melanocortin agonists studied for collagen synthesis, skin remodelling and melanogenesis.

Nootropic & Neuromodulatory

Selank and Semax — Russian-developed neuromodulatory peptides studied for BDNF expression, cognition and anxiolytic activity. Independent purity testing included with every order.

GH Secretagogues

CJC-1295, Ipamorelin, GHRP-2 and Tesamorelin — GHRH analogues and ghrelin-receptor agonists studied for growth hormone release, IGF-1 and body composition. Purity tested by Janoshik.

Or browse the full compound index.

Laboratory Use Only

Everything Valtrax Research ships is bench material for in-vitro work. None of it is a drug, a supplement, a cosmetic, or a medical device, and none of it is intended for human or animal use, ingestion, or administration. Placing an order is your confirmation that you are a qualified researcher buying for lawful research, under every Canadian law and regulation that applies to you.