What is a growth hormone secretagogue?

A compound studied for its ability to stimulate the body to release its own growth hormone, rather than supplying growth hormone itself. The two main classes are GHRH analogues, which act at the growth-hormone-releasing-hormone receptor, and ghrelin-receptor agonists, which act at the growth hormone secretagogue receptor.

What is the difference between CJC-1295 with DAC and without DAC?

The DAC version includes a Drug Affinity Complex that binds serum albumin and extends half-life to several days, producing sustained elevation. Without DAC — Modified GRF (1-29) — the half-life is minutes and the published effect is a short pulse. They are used differently in the literature and are not interchangeable.

Why are Ipamorelin and CJC-1295 studied together?

They act on complementary receptor systems — one at the GHRH receptor, the other at the ghrelin receptor. Published work reports a greater combined GH response than either produces alone, which is the stated rationale in papers that pair them.

Are these peptides tested before they ship?

Yes. Janoshik Analytical independently confirms identity by mass spectrometry and purity by RP-HPLC at 99% or better for every lot.

03 / Shelf

GH Secretagogues Peptides

Growth hormone secretagogues are the peptides studied for their effect on endogenous GH release rather than for supplying growth hormone directly. The shelf splits cleanly in two: GHRH analogues such as CJC-1295 and Tesamorelin, which act at the growth-hormone-releasing-hormone receptor, and ghrelin-receptor agonists such as Ipamorelin and GHRP-2. The published research covers pulsatile GH secretion, downstream IGF-1, body composition and sleep architecture. Every lot is purity tested at 99% or better by an independent laboratory.

5 compounds on this shelf

Research Peptide

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CJC-1295 DAC

$49.99

2mg

CJC-1295 with Drug Affinity Complex. A synthetic analog of growth hormone-releasing hormone. Supplied as a lyophilized powder for research purposes only.

Research Peptide

Ipamorelin

$36.99

2mg

A selective growth hormone secretagogue and ghrelin receptor agonist pentapeptide. Supplied as a lyophilized powder for research purposes only.

Research Peptide

CJC-1295 (No DAC)

$40.00

10mg

A 29-residue GHRH(1-29) analogue without the Drug Affinity Complex, giving a short pulsatile profile. Supplied as a lyophilized powder for research purposes only.

Research Peptide

Tesamorelin

$90.00

10mg

A trans-3-hexenoyl-capped GHRH(1-44) analogue that resists the DPP-4 cleavage which clears native GHRH. Supplied as a lyophilized powder for research purposes only.

Research Peptide

Restocking

GHRP-2 Acetate

TBA

10mg

Growth hormone-releasing peptide-2, a synthetic hexapeptide agonist at the ghrelin receptor (GHS-R1a). Supplied as a lyophilized powder for research purposes only.

GHRH analogues: CJC-1295 with and without DAC

CJC-1295 exists in two forms that are routinely confused, and the difference is the single most important thing to get right on this shelf. The DAC version carries a Drug Affinity Complex that binds serum albumin, extending half-life from minutes to days and producing a sustained elevation in GH and IGF-1. CJC-1295 without DAC — properly Modified GRF (1-29) — has a half-life measured in minutes and produces a sharp pulse instead. The literature treats them as genuinely different tools: sustained exposure and pulsatile exposure have different downstream effects on receptor sensitivity. Tesamorelin is the GHRH analogue with the most developed clinical record, studied specifically for its effect on visceral adipose tissue.

Ghrelin-receptor agonists and selectivity

Ipamorelin and GHRP-2 both act at the growth hormone secretagogue receptor, but they differ in selectivity, and that is what the comparative literature turns on. GHRP-2 produces a strong GH response with measurable effects on cortisol and prolactin. Ipamorelin is the more selective of the two, with published work reporting GH release without the same accompanying hormonal changes. Papers that pair a GHRH analogue with a ghrelin-receptor agonist do so because the two receptor systems are complementary — the combined response reported in that literature exceeds either compound alone.

Reconstitution and storage for GH peptides

These are small peptides, mostly under 4 kDa, and they ship lyophilized. Reconstitute with bacteriostatic water directed against the vial wall, then swirl gently until the cake dissolves. Sustained-release formulations such as CJC-1295 DAC are no more robust than the rest — the DAC modification extends serum half-life, not shelf stability. Keep reconstituted vials refrigerated at 2–8 °C and away from light. Our peptide calculator handles concentration maths for any combination of vial strength and diluent volume on this shelf.

Questions

GH Secretagogues peptides — common questions

What is a growth hormone secretagogue?: A compound studied for its ability to stimulate the body to release its own growth hormone, rather than supplying growth hormone itself. The two main classes are GHRH analogues, which act at the growth-hormone-releasing-hormone receptor, and ghrelin-receptor agonists, which act at the growth hormone secretagogue receptor.
What is the difference between CJC-1295 with DAC and without DAC?: The DAC version includes a Drug Affinity Complex that binds serum albumin and extends half-life to several days, producing sustained elevation. Without DAC — Modified GRF (1-29) — the half-life is minutes and the published effect is a short pulse. They are used differently in the literature and are not interchangeable.
Why are Ipamorelin and CJC-1295 studied together?: They act on complementary receptor systems — one at the GHRH receptor, the other at the ghrelin receptor. Published work reports a greater combined GH response than either produces alone, which is the stated rationale in papers that pair them.
Are these peptides tested before they ship?: Yes. Janoshik Analytical independently confirms identity by mass spectrometry and purity by RP-HPLC at 99% or better for every lot.

Other research shelves

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Tissue Repair & Cytoprotection

BPC-157, TB-500 and KPV — the cytoprotective peptides most cited in the tissue-healing and gut-repair literature. Independent Janoshik purity testing included with every order.

Longevity & Mitochondrial

MOTS-c, NAD+ and SS-31 — mitochondrial-derived peptides and cofactors studied in the longevity, cellular-energy and oxidative-stress literature. Janoshik purity tested.

Or browse the full compound index.

Laboratory Use Only

Everything Valtrax Research ships is bench material for in-vitro work. None of it is a drug, a supplement, a cosmetic, or a medical device, and none of it is intended for human or animal use, ingestion, or administration. Placing an order is your confirmation that you are a qualified researcher buying for lawful research, under every Canadian law and regulation that applies to you.