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Tripeptide · α-MSH(11–13) fragment
Lys-Pro-Val, the alpha-MSH(11–13) tail that keeps the anti-inflammatory signal without the pigmentation activity. Supplied as a lyophilized powder for research purposes only.
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Tested lot by lot at ≥99% purity. The Janoshik certificate for your lot is emailed with the order.
Everything Valtrax Research ships is bench material for in-vitro work. None of it is a drug, a supplement, a cosmetic, or a medical device, and none of it is intended for human or animal use, ingestion, or administration. Placing an order is your confirmation that you are a qualified researcher buying for lawful research, under every Canadian law and regulation that applies to you.
Lys-Pro-Val. The last three residues of α-MSH, and a clean separation of function. Cut the hormone to this tail and the pigmentation activity is gone, but the anti-inflammatory action holds. Studying that residual signal on its own is the point of the fragment.
Three residues also means small enough to use PepT1, the intestinal di/tripeptide transporter, as a way in. The tripeptide is carried straight into epithelial cells — which is why the bench record concentrates on the gut wall and the cytokine output around it rather than on systemic distribution.
Intestinal inflammation is the anchor. Dalmasso fixed two things at once — PepT1 as the uptake route and a measurable drop in colonic inflammatory markers — and the work since has loaded the tripeptide onto targeted carriers, reading colitis severity, cytokine levels, and barrier integrity as the endpoints.
What KPV retains from α-MSH is the anti-inflammatory half, minus the melanocortin-receptor activity — and the literature follows that retained signal into the intestine. Dalmasso mapped the entry route through PepT1 and recorded a fall in colonic inflammation; the targeted-carrier studies that came after were built on top of that finding.
Three readouts recur: NF-κB tone, pro-inflammatory cytokine levels, and epithelial barrier behaviour. Across them the fragment is treated as a compact, transporter-accessible brake applied directly at the gut wall.
It traces to the dissection of α-MSH. With the melanocortin peptides mapped, the open question was which segment carried the anti-inflammatory action without dragging the pigmentary one along — and the answer was the C-terminal Lys-Pro-Val.
The intestinal chapter came later and gave the fragment its working context. PepT1-mediated transport handed KPV a defined route into epithelial cells, and colitis preparations became the models where it was characterized.
Xiao, B. et al. (2017). Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis.
PubMedLaroui, H. et al. (2010). Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.
PubMedDalmasso, G. et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.
PubMedEvery lot is tested for identity, purity, and net content, and the certificate is emailed with the order.
Janoshik Analytical, a laboratory Valtrax does not own, runs the testing — identity by mass spectrometry, purity by RP-HPLC at ≥99%. The certificate covering the lot you receive is also emailed with your order.
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