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NAD+ redox coenzyme · 500 mg
Nicotinamide adenine dinucleotide, the redox coenzyme that shuttles electrons through nearly every cellular redox step. Supplied as a lyophilized powder for research purposes only.
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Tested lot by lot at ≥99% purity. The Janoshik certificate for your lot is emailed with the order.
Everything Valtrax Research ships is bench material for in-vitro work. None of it is a drug, a supplement, a cosmetic, or a medical device, and none of it is intended for human or animal use, ingestion, or administration. Placing an order is your confirmation that you are a qualified researcher buying for lawful research, under every Canadian law and regulation that applies to you.
NAD+ is not a drug candidate — it is one of the oldest pieces of cellular machinery, the dinucleotide that shuttles electrons between nicotinamide and adenine in nearly every redox step a cell runs. As a bench reagent it underwrites enzyme studies, mitochondrial respirometry, and any experiment where the question is energy currency rather than a target.
What keeps it current is consumption. Sirtuins, PARPs, and CD38 all spend NAD+ as a substrate, so its pool size has become a readout in its own right — which is why aging and metabolic-stress models keep coming back to how the molecule is made, used up, and salvaged.
The pool is the throughline. Studies treat NAD+ level and turnover as the dependent variable — measuring how precursor supply, sirtuin/PARP/CD38 consumption, and mitochondrial demand push it up or down, and what those swings do to respiration, oxidative-stress handling, and cell survival.
On the bench NAD+ functions as both reagent and readout. As a cofactor it feeds dehydrogenase studies and respirometry; as a substrate it is steadily drained by sirtuins, PARPs, and CD38, so the size and turnover of the pool become measurable proxies for metabolic state.
The modern literature is built on that drain. Cantò and Trammell trace how precursors feed the salvage route, while Ying’s work maps NAD+ and NADH onto cell-death and oxidative-stress endpoints — together framing the molecule less as a static cofactor than as a balance sheet the cell keeps rewriting.
NAD+ entered biochemistry through fermentation: Harden and Young flagged a heat-stable “coferment” in yeast extract at the turn of the last century, and the structure was pinned down over the decades that followed as the role of the nicotinamide–adenine dinucleotide in respiration came clear.
The contemporary chapter is about the salvage pathway. Once NAD+ was shown to be consumed rather than merely recycled, attention moved to its precursors and to the enzymes that spend it, which is where most current bench work now sits.
Ying, W. (2006). NAD+ and NADH in cellular functions and cell death.
PubMedCantó, C. et al. (2012). The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
PubMedTrammell, S.A.J. et al. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.
PubMedJanoshik Analytical measures identity, purity, and net content, lot by lot.
Janoshik Analytical, a laboratory Valtrax does not own, runs the testing — identity by mass spectrometry, purity by RP-HPLC at ≥99%. The certificate covering the lot you receive is also emailed with your order.
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