Does the vial ship with anything else?

It does not. DSIP is a bench reagent. You get the vial, and its verification record by email — no dosing figure, no administration note, no handling sheet.

12mg of lyophilized DSIP per vial. Measured identity, purity, and net peptide content live on the certificate.

No. The dry peptide is the whole shipment. Reconstitution solvent and every other consumable are the researcher’s to supply.

How long will one vial last?

That is a function of your protocol, working concentration, and storage. It is not a number we can put on the page for you.

DSIP: research-grade, Janoshik-verified peptide

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu — nine residues, and a name that points at an observation rather than a target. DSIP was first recovered from rabbit cerebral venous blood drawn during delta-band sleep, and it carries the EEG signature in its title because that is all the early work could pin to it.

Fifty years later the receptor is still unnamed. That gap is the draw: the peptide turns up in circadian and stress-axis studies not as a solved mechanism but as a recurring loose end the field keeps pulling on.

Where the literature looks

Two strands run through the record — slow-wave sleep and the stress axis — and a single caveat undercuts both: no assigned receptor, plus clearance fast enough to complicate dosing logic in any model. The result is a literature that mostly reports what DSIP travels with rather than how it acts.

Slow-wave EEG and sleep-architecture correlatesEntrainment of circadian and rest–activity rhythmsCrosstalk with the hypothalamic–pituitary stress responseThe unresolved pharmacology — no named receptor, minutes-long half-life

Background

Reported in the mid-1970s, DSIP entered the record through sleep electrophysiology — isolated by its association with slow-wave EEG, then sequenced and made synthetically to confirm the activity survived synthesis. The title encodes that history; it does not encode a pathway.

What the literature actually circles is timing. Studies read DSIP against circadian rhythm and the hypothalamic–pituitary axis, and read it as a correlate more than a cause. The half-life is short, the receptor unassigned, and the picture stays deliberately open.

The starting point was a perfusate: cerebral venous blood collected from rabbits in delta sleep, fractionated until a nine-residue fraction carried the signal. Monnier’s group then ran the synthetic nonapeptide back through the test to check the activity held. Sleep physiology framed the first wave of models.

After that the subject widened — stress reactivity, rhythm entrainment, endocrine cross-talk — without ever resolving onto a single mechanism. DSIP has stayed in the literature precisely as an unsettled case rather than a closed one.

A structured evidence summary for this item is still being written. The primary literature listed under Molecule is the starting point in the meantime.

Primary sequence

1Trp2Ala3Gly4Gly5Asp6Ala7Ser8Gly9Glu

Molecular constants

FormulaC₃₅H₄₈N₁₀O₁₅

Mol. weight848.81 g/mol

CAS62568-57-4

PubChem CID68816

Primary literature

01
Monnier, M. et al. (1977). The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide.
PubMed
02
Schoenenberger, G.A. et al. (1978). The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. Pflugers Arch 376(2):119–129.
PubMed
03
Schneider-Helmert, D. et al. (1981). Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. Int J Clin Pharmacol Ther Toxicol 19(8):341–345.
PubMed
04
Schneider-Helmert, D. & Schoenenberger, G.A. (1981). The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep.
PubMed
05
Graf, M.V. & Kastin, A.J. (1984). Delta-sleep-inducing peptide (DSIP): a review.
PubMed
06
Schoenenberger, G.A. (1984). Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP).
PubMed
07
Graf, M.V. & Kastin, A.J. (1986). Delta-sleep-inducing peptide (DSIP): an update.
PubMed
08
Schneider-Helmert, D. et al. (1987). Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia. Eur Neurol 27(2):120–129.
PubMed
09
Pollard, B.J. & Pomfrett, C.J.D. (2001). Delta sleep-inducing peptide.
PubMed
10
Kovalzon, V.M. (2006). Delta sleep-inducing peptide (DSIP): a still unresolved riddle.
PubMed

Purity

The certificate for your lot reports measured identity, purity, and net content, and is sent by email.

12mg

Tested by Janoshik

Janoshik Analytical, a laboratory Valtrax does not own, runs the testing — identity by mass spectrometry, purity by RP-HPLC at ≥99%, on the lot you receive.

Does the vial ship with anything else?: It does not. DSIP is a bench reagent. You get the vial, and its verification record by email — no dosing figure, no administration note, no handling sheet.
What is the fill?: 12mg of lyophilized DSIP per vial. Measured identity, purity, and net peptide content live on the certificate.
Is solvent included?: No. The dry peptide is the whole shipment. Reconstitution solvent and every other consumable are the researcher’s to supply.
How long will one vial last?: That is a function of your protocol, working concentration, and storage. It is not a number we can put on the page for you.

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