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Tuftsin-derived heptapeptide · Thr-Lys-Pro-Arg-Pro-Gly-Pro
A tuftsin-derived heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) stabilized by a Pro-Gly-Pro tail. Supplied as a lyophilized powder for research purposes only.
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Tested lot by lot at ≥99% purity. The Janoshik certificate for your lot is emailed with the order.
Everything Valtrax Research ships is bench material for in-vitro work. None of it is a drug, a supplement, a cosmetic, or a medical device, and none of it is intended for human or animal use, ingestion, or administration. Placing an order is your confirmation that you are a qualified researcher buying for lawful research, under every Canadian law and regulation that applies to you.
Selank takes the immune-active tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and welds a Pro-Gly-Pro tail onto it — the same stabilizing trick used on Semax, and for the same reason: a bare four-residue peptide would not last long enough to study. The result is a seven-residue molecule with a half-life worth working with.
The parentage steers the questions. Tuftsin carries immunomodulatory and neuro-regulatory history, and the literature on Selank follows both threads, leaning toward GABA/serotonin-adjacent readouts and the BDNF end of things rather than a single named receptor.
With no assigned receptor, the record is built on consequences rather than binding. Studies measure what Selank does to monoamine and GABAergic signaling, to BDNF in hippocampus and prefrontal cortex, and to cytokine profiles under stress — using behavioral anxiety and withdrawal models as the proving ground.
Selank does not have a tidy single-receptor story, and the research reflects that. Instead of one binding site, the work tracks downstream signatures — shifts in monoamine balance, modulation of GABAergic tone, and changes in BDNF and cytokine expression — treating those as the fingerprint of its activity.
The Russian-origin literature is where most of it sits. Kolik’s BDNF work in hippocampus and prefrontal cortex, Yasenyavskaya’s cytokine readouts under social stress, and Konstantinopolsky’s withdrawal models together sketch a peptide studied through its effects on neurochemistry rather than a named target.
Selank was designed at the Institute of Molecular Genetics in Moscow as a stabilized analogue of tuftsin — the goal being to keep tuftsin’s regulatory activity while extending a half-life too short to be useful on its own. The Pro-Gly-Pro extension solved the durability problem.
From there the research program broadened from the immune-peptide roots of tuftsin into anxiety, stress, and cognition models, the areas where the bulk of the published Selank work now lives.
Konstantinopolsky, M.A. et al. (2022). Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
PubMedYasenyavskaya, A.L. et al. (2021). The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Curr Rev Clin Exp Pharmacol 16(2):169–173.
PubMedKolik, L.G. et al. (2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.
PubMedVanhee, C. et al. (2020). The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the third kind. Drug Test Anal 12(1):63–73.
PubMedThe certificate for your lot reports measured identity, purity, and net content, and is sent by email.
Janoshik Analytical, a laboratory Valtrax does not own, runs the testing — identity by mass spectrometry, purity by RP-HPLC at ≥99%. The certificate covering the lot you receive is also emailed with your order.
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